Eco Friendly CBD OIL
The Best Eco Friendly CBD Oil
by CBD OIL
Premium Broad Spectrum CBD Tincture
Our pure, organic CBD tinctures from the region have a broad spectrum without THC. They’re packed with beneficial cannabinoids and delicious terpenes – making them your solution to feeling your best all day
The post Citizen hemp first appeared on CBD health and wellness.
by CBD OIL
Cannabidiol (CBD) is well tolerated and is often used in the form of prescription Epidiolex®. It is sold over the counter and over the Internet nationwide. This cannabinoid is legal because it is made in the hemp plant that produces little tetrahydrocannabinol (THC) and for which cultivation became legal in 2018. [1] CBD facilitates various well-studied pharmacological effects on the body such as anxiety relief, anti-inflammatory, neuroprotection, antipsychosis, and anti-epilepsy. [2]
CBD offers a unique mechanism of action for multiple disease targets for which few other treatment options exist. Cannabidiol does not act selectively on a single receptor in the human body like many drugs. Activity on multiple receptors enables a wide range of medicinal benefits, but also enables the potential for drug interactions. [2]
Potential adverse interactions occur primarily in the liver, where drugs are metabolized and detoxified by a group of enzymes Cytochrome enzymes. Negative side effects can occur when the same detoxifying enzyme is responsible for a variety of drugs. Other drugs like lorazepam and even popular diet products like caffeine can have significant interactions with CBD in the liver.
Two of the most common side effects seen when administering CBD are drowsiness and sedation. [2]
Currently, CBD is ingested by millions of people without prior assessment of age, health, current medical conditions, genetic analysis, or current drug use. Because of its widespread use, a thorough understanding of the adverse effects and potential toxicity of CBD is required. Even so, the incidence of side effects is considered to be low and benign compared to traditional drug treatments.
One of the overarching problems with CBD is its inconsistency with what products are available online or in retail stores. Mislabeling, inaccurate concentrations and contamination are common risks that can lead to additional and unpredictable adverse effects. [3] Ultimately, the dosage forms (i.e. capsules, tinctures, vapes, etc.) of CBD lead to variations Bioavailability in the body; Combined with the wide dosage range (~ 10 mg – 2,000 mg) of CBD, this can lead to potential side effects and toxicity. [4]
As CBD becomes more popular, standardized methods of making and analyzing CBD are certain to emerge. Doctors can evaluate the patient’s condition and medications to ensure maximum benefits and minimal side effects.
picture:: Erin_Hinterland of Pixabay
References::
by CBD OIL
A new open label study [1] Research into the effects of cannabidiol-based (CBD) Epidiolex® for the treatment of Parkinson’s disease found the compound had beneficial effects in patients as CBD continues to be used to treat the disease despite fewer medical studies.
The study used 100 mg / ml Epidiolex for 10 to 15 days in participants with Parkinson’s disease. The dose was titrated from 5 to 20-25 mg / kg / day; For a 150 pound person, that’s roughly 340 mg up to 1,700 mg per day. In this study the dose ranged up to 3,460 mg / day.
A total of 10 participants reported a mix of side effects and benefits resulting from the treatment. Side effects included diarrhea, abdominal pain, headache, and increased appetite. Three other participants left the study due to an “intolerance” to treatment with Epidiolex. The authors state that diarrhea “could be related to sesame oil”. No adverse event was considered serious.
However, benefits were noted after 10 to 15 days, including improved motor function, night sleep, and behavior / emotional control. These benefits persisted for two weeks after discontinuation. The researchers speculate that the interactions of CBD with the Serotonin system and other non-cannabinoid signaling systems may be responsible. For example, CBD indirectly increases dopamine through the G-coupled protein receptor GPR6.
They quickly indicated that five patients had elevated liver enzymes, which they attribute to the high maximum dose. These and all other side effects resolved when CBD was discontinued.
Overall, the researchers concluded that CBD can have positive results in treating Parkinson’s. Randomized controlled trials will be needed to really determine its effectiveness in treating the disease. This is another positive development in studies looking at the effectiveness of CBD in treating a whole Variety of conditions, not just Parkinson’s.
References:
Photo courtesy of CrystalWEED cannabis
by CBD OIL
Everyone is excited about the potential medicinal benefits of cannabidiol (CBD). A recent article reviewed clinical and human observational studies on CBD dosage, effectiveness, and safety. [1] This review looked at 25 published studies from 2000 to 2019 that enrolled over 900 patients in five different countries.
CBD for anxiety, psychosis, substance abuse disorders, and more
Positive effects of CBD have been reported in the majority of studies examining CBD for anxiety. schizophreniaand nicotine addiction.
Positive effects on par with an antipsychotic have been observed when CBD was administered to patients with acute psychotic symptoms. However, CBD had no significant benefit for patients with chronic schizophrenia who were also treated with antipsychotics. This could indicate that CBD is best used in the early stages of schizophrenia. Here the dosages and delivery methods were used:
Large single doses were effective for social anxiety. In addition, small doses (16-32 mg) increased the fear of extinction in healthy subjects.
A couple of studies to look at epilepsySkin diseases and adverse drug reactions after HPV vaccination supported the use of CBD.
CBD for diabetes, Crohn’s disease and ulcerative colitis
Type 2 diabetes, Crohn’s disease, and ulcerative colitis have also been the subject of studies. These studies – only one study for each condition – used CBD doses ranging from 20 mg to 250 mg per day for different periods of time. They showed little or no effect from CBD treatments.
CBD side effects and risks
CBD side effects of fatigue, diarrhea, and changes in appetite / weight have been reported but are rarely severe. It is reported that CBD is always having fewer serious side effects than traditional drugs used to treat epilepsy and psychotic disorders. The authors emphasize: “Compared to other drugs, a better side effect profile was presented.”
CBD formulation and delivery methods
CBD isolate has one bell-shaped activity curveThis means it works best between low or high doses. Researchers believe that full-spectrum CBD may be due to the “Entourage effect. “Since most studies use CBD isolate, results may be worse than using full-spectrum CBD, which contains additional plant compounds such as terpenes and flavonoids. The dose of CBD can also vary depending on the delivery method. Tinctures, capsules, vapes, and topical products have different activation times and dosage considerations. Oral CBD in particular is known for its relatively low bioavailability.
Future CBD Research
Larsen and Shahinas [1] End their review by stating that these studies are a good start, but going forward, researchers will need to study larger and more diverse groups of people. They also recommend that studies consider full-spectrum CBD and other delivery methods.
Image: add weeds Unsplash
References
by CBD OIL
Rhode Island could become the first state where pets qualify for medical cannabis. The proposed invoice would give veterinarians legal authority to prescribe medicinal cannabis to pets for “any condition in a pet that would be a” debilitating medical condition “if suffered by a person.”
“Some people may poke fun at this bill, but those of us who have or have had pets know that many of us consider them to be members of our extended family.” said West Warwick Democratic MP Patricia Serpa, who sponsored the bill, and William O’Brien and Stephen Casey, also Democratic representatives: “And we will go to great lengths to provide them with comfort and wellbeing, either with chronic illness or with chronic illnesses a condition at the end of life. “
The idea of medical cannabis for pets has been around for some time. Michigan Governor Gretchen Whitmer signed legislation Allow veterinarians to discuss Cannabis / hemp as a pet remedy with owners (rather than recommending and prescribing it).
In 2019 in California seemed ready became the first state to allow medical cannabis for pets, but that didn’t come to fruition, and medical cannabis for pets stayed at what it is now in Michigan.
In 2018 a invoice New York tried to do what this current Rhode Island hopes to do, but nothing came of it.
The Rhode Island Veterinary Medical Association has made its position clear on the matter – stern disapproval and opposition over the toxicity of tetrahydrocannabinol (THC) to dogs.
“Emergency hospitals report up to 10 cases of [cannabis] Daily pet poisoning, ”read a letter to the Rhode Island House Committee on State Government and Elections. There are no FDA approved cannabis products for pets.
Dr. Ralph Pratt, a veterinarian at West Greenwich Animal Hospital and a member of the board of directors of the Rhode Island Veterinary Medical Association, notes that their stance on THC for pets doesn’t close the door on CBD. Benefits of CBD for dogs include conditions such as neurodegenerative disorders, anxiety, inflammation, and epilepsy.
Credit: Erin_Hinterland / pixabay
by CBD OIL
Elevated Wellness Delta-8 Tinctures are superior D8 tinctures made from organic and compliant material with a fully compliant process and are free of any possible contaminants.
Our D8 tinctures are infused with a small percentage of our Focus terpenes and a small percentage of CBN, Delta-6A / 10A and other beneficial phytocannabinoids.
Delta-8 is a recently discovered cannabinoid that is found in very low proportions in the cannabis / hemp genome. Like CBN, we must make it in a certified and compliant laboratory by forcing a reaction to convert CBD to near-pure Delta-8 (effectively creating an isomer of the natural cannabinoid in high concentrations). Again, our Delta-8 tinctures are infused with a small amount of CBN, Delta-6A / 10A, and other minor phytocannabinoids (with a very small percentage), as well as a small percentage of terpenes.
Your safety is our top priority. That is why we test our Delta-8 like all other products that we manufacture and sell in full panel.
by CBD OIL
Cannabidiol (CBD) is so popular that it can practically sell itself. Still, any establishment selling CBD still needs a comprehensive strategy to promote their products that is not only effective but also within the law. Since the 2018 bill legalizing hemp and its derivatives, including CBD, many companies have had problems with and received legal issues related to the promotion of their products Warning letters from the Food and Drug Administration (FDA). Fortunately, there are ways for companies to ensure that their marketing activities stay within the laws and regulations set by the FDA.
A large number of letters The information released in recent years has been sent to companies making illegal claims that their CBD products can be used to “prevent, diagnose, alleviate, treat or cure various diseases.” This directly violates the Federal Food, Drugs, and Cosmetics Act (FD&C Act). If a company wants to assert such claimstheir product must be “FDA approved or conform to a” monograph “for a specific drug category as determined by the FDA’s over-the-counter drug review before they can be legally marketed as a drug”. And CBD is not verified by OTC. A company can also receive a warning letter if it sells an unapproved OTC drug that has CBD listed as an inactive ingredient.
This ban on advertising CBD as a medicinal product applies not only to products intended for human consumption, but also to products intended for animal consumption. In addition, there is CBD not confirmed as a food additive still approved as a food supplement.
When a company receives a warning letter, it has 15 working days Responding to the FDA to prove that the legal issue was addressed or to respond with an argument about why their product is not in violation of the law.
The FDA is closely monitoring CBD products and is currently developing comprehensive regulations and guidelines for their manufacture, marketing, and sale. CBD companies need to follow FDA developments closely to stay on the right side of the law. As such, companies should hire legal counsel to ensure their actions are fully in line with the FDA. This saves time, money, and effort, and helps ensure these companies have a bright future in the evolving CBD market.
Credit: comment
Image source: https://pixabay.com/photos/sign-stop-warning-stop-sign-symbol-1732791/
by CBD OIL
Judging by their names, cannabidiol (CBD) and cannabinol (CBN) may seem like first cousins, but this is simply wrong, as their origins and their mode of action are fundamentally different. Nevertheless, they have some things in common and can even complement each other.
For starters, CBN is the result of THC oxidation. When tetrahydrocannabinol (THC) is exposed to heat, light, and / or time, it converts to CBN. This makes CBN a very sparse cannabinoid. Conversely, CBD is the second most important cannabinoid, although it also comes from a different molecule.
That sounds a little bit humiliating towards CBN, and while it is literally “degraded” THC, it has some nice perks too.
Like CBD, CBN is non-intoxicating. That being said, it is ultimately the by-product of THC and as such binds to cannabinoid 1 (CB)1) Receptor, even if only at about 10% of the THC affinity.[1] For this reason, the anecdotal evidence that the effects of CBN can border on mild poisoning seems plausible.
Considering that like THC, the apple doesn’t fall far from the tree, it was also found in preclinical research that CBN increased appetite while CBD actually decreased food consumption.[2] The feeding effects of CBN, if backed by further study, could be a great alternative to using THC for people facing loss of appetite.
On the other hand, it is believed that CBD negates or offsets the psychoactive effects of THC and in particular side effects such as paranoia.[3]
However, CBN and CBD have been studied together in the context of pain relief in preclinical models. Both cannabinoids were found to relieve myofascial pain, and combination treatment increased the effects.[1] These results indicate that despite their different properties, these two compounds may work better together in some conditions such as chronic pain.
In addition, like CBD, CBN can have anti-inflammatory and antispasmodic properties.[4] While many people claim that CBN could help with sleep, there is no data to effectively back it up.
As you can see, CBN and CBD are very different, but share some similarities. This is a recurring theme in cannabis science as a whole that may be at the core of the entourage effect and the unique relationship that cannabinoids share like a group of best friends united and completed by their differences.
New information about the little cannabinoids doesn’t let the CBD benefits out of the window! Instead, it offers options to try these new isolate compounds or use them in combination with CBD to see what they can do together.
Credit: Alex Green
Image source: https://www.pexels.com/photo/couple-wearing-couple-outfit-6626094/
References:
The post CBD versus CBN first appeared on CBD health and wellness.
by CBD OIL
Over the years there has been great interest in the Benefits of the entourage effect. This is where all of the molecular components of the cannabis plant, including cannabinoids, terpenes, and other phytonutrients, work together to support and potentially enhance each other’s medicinal properties.
A study published in late 2020 compared full-spectrum cannabidiol (CBD) oils with CBD isolates to assess their effects on cancer cells.[1] The study focused on six cancer cell lines from three human cancers: colon cancer, melanoma, and glioblastoma. Using cell cultures, the six cancer lines were treated with commercially available CBD oils or CBD isolate. The cell cultures were then monitored for 48 hours before cancer cell viability was measured.
All three CBD oils used in this study were evaluated through third-party laboratory tests to confirm their content and purity. A second round of confirmatory testing revealed very few inconsistencies: “Each oil was independently tested to be within 8% of the stated CBD concentration.”[1] The oils were also subjected to terpene, chlorophyll and carotenoid content analysis.
The study found that the CBD isolate was most effective at reducing cell viability in three of the six lines tested when compared to full-spectrum CBD. The authors therefore concluded that the entourage effect did not appear to potentiate the effects of CBD on cell viability in the cancer lines tested. One worrying note was that some of the oils appeared to protect cancer cells from the CBD.
It’s important to note the wide variety of CBD formulations and full spectrum products to choose from. With higher levels of different cannabinoids or different terpene mixtures (their oils contained alpha and beta ferns, transcaryophylls, alpha humulene, and alpha bisbolol) they could have had very different results.
So this study does not mean that the entourage effect is not real, but it does suggest that the entourage effect is absent when using CBD oils to reduce the viability of cancer cells in tissue cultures under the specific conditions examined here. These results indicate that not only the entourage effect, but also the use of certain oils as carriers for cannabinoids such as CBD, needs further investigation.
Credit: Doodlart
Image source: https://pixabay.com/illustrations/stem-cells-embryonic-dna-3d-5004507/
reference
by CBD OIL
Pain due to a variety of diseases including Fibromyalgiaassociated with significant, widespread pain can be effectively reduced through the use of cannabidiol (CBD). However, research on CBD and its effects on this condition has been limited so far.
A recent survey looked at patterns of CBD use among fibromyalgia patients to better understand how often CBD is used, why it is used, and how patients with fibromyalgia rate the effectiveness and safety of CBD for relieving their symptoms.[1]
Approximately 2,700 fibromyalgia patients who used CBD were surveyed. Of those surveyed, around 30% have used CBD in the past and a third said they are currently using CBD. 38% of respondents said they had never used CBD and cited safety concerns. The patients currently using CBD, or those who have used it in the past, stated that they consumed the cannabinoid to obtain relief from their pain after inadequate relief from conventional drugs.
Patients who used CBD did so for several symptoms associated with fibromyalgia, including joint stiffness and muscle cramps, as well as poor sleep and anxiety.[1] Those who used CBD typically reported an improvement in symptoms ranging from mild to strong improvement as follows: 30.5% for pain, 40.1% for insomnia / sleep disorders, 40.0% for anxiety, 20% for fatigue, 32.3% for depression and 21.9% for memory / clarity of thinking. Minor side effects have been reported, with drowsiness being the most common.
It is interesting to note that 95% of the respondents were female. Therefore, it is not known whether male patients use CBD at similar rates. In addition, despite high usage rates, less than 30% said they would discuss CBD with their doctor.
Respondents’ responses suggest that CBD use is common in fibromyalgia sufferers and that the cannabinoid is relatively effective in relieving pain and associated anxiety and lack of sleep. Patients and their doctors should discuss the use of CBD and its inclusion in a fibromyalgia treatment plan.
Credit: Wolfgang Claussen
Image source: https://pixabay.com/photos/figure-man-stand-back-pain-1707104/
reference