CBD OIL

Like any other natural product, the biomass of legal cannabis can be contaminated by several toxic agents such as heavy metals, organic solvents, microbes and pesticides, which significantly influence the safety of the end products.

Let’s just consider the toxicological effects. Since cannabis products are not only administered in edible forms but also smoked and inhaled, unlike most agricultural products, pesticide residue poses an unpredictable risk to consumers. One example is the potential role of myclobutanil in the vape crisis.

Unfortunately, federal and state laws are still conflicted on cannabis-related pesticides. Currently, only ten pesticide products have been registered specifically for hemp by the U.S. Environmental Protection Agency. So, the question arises what has to be done with all pf the high-value, but also contaminated cannabis, keeping in mind that during the extraction processes, not only the phytocannabinoids get concentrated but the pesticides as well, reaching concentrations up to tens or hundreds of parts per million!

Currently, there are three different sets of rules in place in the regulatory areas of Oregon, California and Canada. These regulations detail which pesticides need to be monitored and remediated if a certain limit for each is reached. Because the most extensive and strict regulations are found in Canada, RotaChrom used its regulations as reference in their case study.

To illustrate that reality sometimes goes beyond our imagination, we evaluated the testing results of a THC distillate sample of one of our clients. This sample contained 9 (!) pesticides, of which six levels exceeded the corresponding action limits. The most frightening, however, regarding this sample, is that it contained a huge amount of carbofuran, a category I substance. It is better not to think of the potential toxicological hazard of this material…

The CPC-based purification of CBD is a well-known and straightforward methodology. As the elution profile on the CPC chromatogram of a distillate shows, major and minor cannabinoids can be easily separated from CBD. At RotaChrom, this method has been implemented at industrial-scale in a cost effective and high throughput fashion. In any case, the question arises: where are the pesticides on this chromatogram? To answer this, we set ourselves the goal to fully characterize the pesticide removing capability of our methodologies.

Our results on this topic received an award at the prestigious PREP Conference in 2019. The ease of pesticides removal depends on the desired Compound of Interest.

Here is a quick recap on key functionalities of the partition chromatography.

• Separation occurs between two immiscible liquid phases.
• The stationary phase is immobilized inside the rotor by a strong centrifugal force.
• The mobile phase containing the sample to be purified is fed under pressure into the rotor and pumped through the stationary phase in the form of tiny droplets (percolation).
• The chromatographic column in CPC is the rotor: cells interconnected in a series of ducts attached to a large rotor
• Simple mechanism: difference in partition

Let’s get into the chemistry a bit:

The partition coefficient is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquid phases.

The CPC chromatogram demonstrates the separation of Compounds of Interest based on their unique partition coefficients achieved through a centrifugal partition chromatography system.

CPC can be effectively used for pesticide removal. About 78% of the pesticides around CBD are very easy to remove, which you can see here:

In this illustration, pesticides are in ascending order of K_d from left to right. CBD, marked with blue, elutes in the middle of the chromatogram. The chart illustrates that most polar and most apolar pesticides were easily removed beside CBD. However, some compounds were in coelution with CBD (denoted as “problematic”), and some compounds showed irregular K_d-retention behavior (denoted as “outliers”).

If pesticides need to be removed as part of THC purification, then the pesticides that were problematic around CBD would be easier to remove and some of the easy ones would become problematic.

To simulate real-world production scenarios, an overloading study with CBD was performed, which you can see in the graph:

It is easy to see on the chromatogram that due to the increased concentration injected onto the rotor, the peak of CBD became fronting and the apparent retention shifted to the right. This means that pesticides with higher retention than CBD are more prone to coelution if extreme loading is applied.

To be able to eliminate problematic pesticides without changing the components of the solvent system, which is a typical industrial scenario, the so-called “sweet spot approach” was tested. The general rule of thumb for this approach is that the highest resolution of a given CPC system can be exploited if the K_d value of the target compounds fall in the range of 0.5-2.0. In our case, to get appropriate Kd values for problematic pesticides, the volume ratio of methanol and water was fine-tuned. Ascending mode was used instead of descending mode. For the polar subset of problematic pesticides, this simple modification resulted in an elution profile with significantly improved resolution, however, some coelution still remained.

In the case of apolar pesticides, the less polar solvent system with decreased water content in ascending mode provided satisfactory separation.

Moreover, if we focus on this subset in the three relevant regulatory areas, the outcome is even more favorable. For example, myclobutanil and bifenazate, dominant in all of the three regulatory regions, are fully removable in only one run of the CPC platform.

Based on these results, a generic strategy was created. The workflow starts with a reliable and precise pesticide contamination profile of the cannabis sample, then, if it does not appear to indicate problematic impurity, the material can be purified by the baseline method. However, if coeluting pesticides are present in the input sample, there are two options. First, adjusting the fraction collection of the critical pesticide can be eliminated, however the yield will be compromised in this case. Alternatively, by fine-tuning the solvent system, a second or even a third run of the CPC can solve the problem ultimately. Let me add here, that a third approach, i.e., switching to another solvent system to gain selectivity for problematic pesticides is also feasible in some cases.

In review, RotaChrom has conducted extensive research to analyze the list of pesticides according to the most stringent Canadian requirements. We have found that pesticides can be separated from CBD by utilizing our CPC platform. Most of these pesticides are relatively easy to remove, but RotaChrom has an efficient solution for the problematic pesticides. The methods used at RotaChrom can be easily extended to other input materials and target compounds (e.g., THC, CBG).

The explosive, unregulated growth of delta-8 tetrahydrocannabinol (THC) is coming with a dangerous consequence: Poison control centers across the country are reporting a rise in calls from those who have ingested the cannabinoid. 

At least four states have issued public warnings regarding the cannabinoid, according to local news reports: Michigan, West Virginia, Virginia and North Carolina.

So far this year, as of July, the North Carolina Poison Control Center reported 157 cases related to delta-8, according to the Winston-Salem Journal. Virginia is reporting “dozens” of calls this year.

The rise in calls can be attributed to a number of factors, from the market’s lack of standards to delta-8’s accessibility to minors.

But perhaps the most concerning cause for an increase in delta-8 poison center calls is due to mislabeling–in some cases, consumers hoping to buy these products may be purchasing unregulated, illegal cannabis without knowing.

“This is part and parcel for what happens when you have an unregulated market,” says Jonathan Miller, general counsel for U.S. Hemp Roundtable. 

Mislabeling Plays a Role

A recently published report shines a light on just how prominent mislabeling is in the industry.  Leafreport.com, a peer-reviewed watchdog website for the cannabidiol (CBD) industry, found that more than half of the 38 products it tested had illegal levels of delta-9 THC. In addition, only 32% had the advertised amount of delta-8. The rest were off by 10.7% to 102.7% from the label.

And Wayne State University, based in Michigan, reports that law enforcement agencies in Michigan have seized delta-8 products that were falsely labeled as CBD products.

Lev Spivak-Birndorf, Ph.D., chief science officer at PSI Labs, a Michigan-based cannabis testing lab, says the mislabeling of these products could be linked to the risks associated with producing delta-8, as byproducts can be left during the process of converting it from CBD or delta-9 THC.

For example, when labs extract cannabis to make other oils, it’s a more straightforward process, as there are already established and known solvents and methods, like butane or ethanol extraction, that labs can use to remove byproducts, Spivak-Birndorf says.

“But once you get into the process of converting CBD into delta-8, it’s called chemical synthesis,” he says. “You’re essentially taking one molecule and performing a chemical reaction that’s causing it to change into another molecule via that reaction.”

There are several standard operating procedures (SOPs) that can be used to extract delta-8; however, there are many “variables in terms of what can be left over in the product and how dangerous the substance is that labs use to catalyze that reaction and make it occur at a speed that’s acceptable for production,” he says.

PSI Labs has not yet conducted extensive research into what type of contaminants can be found in delta-8 products due to costs; however, the laboratory has brought in off-the-shelf delta-8 products from places like vape shops and gas stations for testing, and they’ve discovered discrepancies in the products.

“We often find that some of [the products] are very pure delta-8, but still contain traces of delta-9 that are technically above the legal 0.3% THC limit,” he says. “It’s just a mixed bag, and that’s what I think is so risky about it, is that it’s very uncontrolled in terms of these processes, where one product could be pretty genuine to its label, but another one might be very different.”

RELATED: Understanding Delta-8-THC: Where Does It Come From?

Allison Justice, Ph.D., CEO of The Hemp Mine, previously told Hemp Grower that in the delta-8 extraction process, the final distillate ends up being 60% to 70% delta-8 and roughly 2% to 6% delta-9. Suppose a company wants to make a compliant product with the U.S. Department of Agriculture’s (USDA’s) final rule on hemp. In that case, they will then run the distillate through extensive chromatography to remove the delta-9 or dilute it down to ensure it’s under the 0.3% THC limit, she said.

But Spivak-Birndorf says PSI Labs has found off-the-shelf delta-8 products that contain 20% delta-9, as well as a significant amount of CBD, meaning that whatever reaction pathway they chose, they didn’t finish it and left it “half-cooked,” he says.

“This raises lots of questions about what residual other byproducts might be in [the delta-8 products] that are sort of not familiar cannabinoids, but maybe harmful substances, like heavy metals, which can often be used in these processes,” he says.

Spivak-Birndorf says PSI Labs has come across many delta-8 vapes over the 0.3% THC limit; however, he thinks the real risk with mislabeling is with edibles. 

“Once you eat [the edible], that’s how much you eat, and you really can’t go back from there. So, that’s where testing is absolutely critical,” he says. “You really need to test things in a fashionable manner to make sure that there’s nothing wrong with your process. Other packaged and ready-made goods go through many good manufacturing practices (GMPs) and Food and Drug Administration (FDA) guidelines before they get to the shelf. In the cannabis industry, a lot of that stuff is non-existent or just catching up.”

Spivak-Birndorf says there is a need for third-party, end-product testing on a batch basis to ensure the products are correctly dosed before hitting shelves because there are not many regulated delta-8 testing and measurement practices in place.

“All of this is an important part of a good manufacturing practice of what goes into all the packaged goods we consume,” he says. “And so really, it should be implemented for delta-8 or delta-9, just like anything else.”

“There’s no reason to limit ourselves in terms of the cannabinoid toolbox,” he adds. “Whether it’s naturally occurring, semi-synthetic or even synthetic, it’s very important to know exactly what we’re dealing with and what quantities we’re dealing with if we want to avoid unknown adverse reactions and keep people as safe and healthy as possible.”

Minors the Main Victims

According to the Wayne State University report, in a nearby state, there were two reported cases of severe adverse reactions to delta-8 in children who ingested their father’s edibles purchased at a vape shop.

The report says that because delta-8 products are packaged in similar forms of CBD, teens and young children have a higher risk of using the compound accidentally. “THC use in children can cause low blood pressure, difficulty breathing, severe sedation, coma, and psychological effects. Long-term effects in children are not known,” the report says.

According to the National Capital Poison Center, because delta-8 products are largely unregulated, “the packaging may not be child-resistant and may contain cartoon-like images or other features that may be appealing to children.”

On its website, the National Capital Poison Center offers this anecdote: “A 3-year-old boy was brought to an Emergency Department after eating an unknown amount of delta-8 THC gummies belonging to his mother. The gummies were packaged in a container with a twist-off top, and the boy was able to open the container by himself. The child experienced vomiting but was eventually released from the hospital. His mother was cited for child abuse and neglect.”

Market Regulation Needed

Spivak-Birndorf says there is an increased need for regulation, as it is difficult to trace where these unsafe delta-8 products are coming from.

“While some of these companies have an online presence and show current testing and are actually responsible, for every one of those, there’s probably, and I would guess, numerous [companies] that are flying by night and just not checking their work,” he says. “Or they’re not concerned about quality control checks for their product, which they should have. So, definitely without that regulatory push to do all that stuff, it’s unrealistic to think that [everyone] is just going to take that upon themselves.”

As previously reported by Hemp Grower, Michigan has recently joined numerous other states in regulating delta-8, as Gov. Gretchen Whitmer signed legislation into law July 13, prohibiting businesses from selling delta-8 products without proper licensing from the Michigan Marijuana Regulatory Agency, and the products must be tracked and tested like any other cannabis product. 

Additionally, “the new law also bars businesses without state cannabis licenses from producing and selling any other potentially intoxicating cannabis compounds,” Hemp Grower previously reported.

And in late April, Hemp Grower reported that Washington’s Liquor and Cannabis Board (LCB) issued a policy statement, stating that “Delta-8 THC, as well as derivatives, extracts, cannabinoids, isomers, and CBD isolate from hemp or other sources that are genetically or chemically altered into compounds may not be produced or processed in LCB licensed facilities, and may not be sold in licensed marijuana retail stores.”

However, this does not necessarily mean delta-8 is outright banned in the state, as the LCB’s notice “was only an interpretation of the law as it relates to the legal cannabis market,” Hemp Grower reported.

Washington and Michigan are just two of nearly 20 states that have already regulated the cannabinoid. According to Hemp Grower, 15 states have issued bans on delta-8, while six additional states have pending legislation to regulate the cannabinoid and related THC isomers. 

Miller says the U.S. Hemp Roundtable has been working with states on developing laws that regulate delta-8 under the cannabis market because of its psychoactive properties. So far, Michigan, Oregon and New York have passed similar laws.

“I would very much hesitate buying a delta-8 product” in the current market, Miller says. “I would only buy things available in a dispensary that have been proven to undergo the same type of testing [as regulated cannabis].”

Not Just Delta-8

Delta-8 isn’t the only cannabinoid responsible for an uptick in poison center calls this year.

As of June 30, the American Association of Poison Control Centers (AAPCC) reported that poison control centers across the country had managed 2,158 cases in 2021 related to CBD. This is nearly on par with the 2,226 calls placed the entire year in 2020.

For perspective, in June 2020, poison control centers handled 181 cases related to CBD; in June 2021, that number jumped to 423.

The AAPCC offers this explanation on its website for the increase in calls: “…[S]ome products contain more CBD than what is on the label, more THC than labeled, or other chemical compounds/drug ingredients that are not listed at all. Consumers have no way of knowing whether the product is contaminated with other chemicals and drugs or labeled correctly.”

© Chart Courtesy of The American Association of Poison Control Centers

Miller points out that CBD is “a safe compound, and study after study have demonstrated its safety.” But without clear regulations or even guidance on how to produce CBD products, it’s possible the products contributing to poison control center cases don’t comply with GMP safety standards, Miller says.

“The challenge is that we’re in an unregulated marketplace,” he says. “These kinds of problems are hopefully going to spur Congressional action that will pass bills to develop a regulatory structure.”

Miller adds that the Hemp Access and Consumer Safety Act moving through the U.S. Senate would require the U.S. Food and Drug Administration to develop a regulatory pathway for CBD to be used in food, beverages and dietary supplements.

You can reach your local poison control center by calling the Poison Help hotline: 1-800-222-1222. To save the number in your mobile phone, text POISON to 797979.

 

Cannabis testing is important for both operators and consumers, but there are some differences in what is important to each group. Obviously, safety and efficacy are important to both. Cannabis is primarily tested for safety reasons to ensure that consumers are receiving a product that is safe to consume and accurately labeled. In addition, consumers may look for a potency they’re used to consuming or a certain terpene profile that gives them a desired effect. Cannabis operators, on the other hand, use testing results to improve their processes and to monitor product quality versus state specific regulatory requirements that could cause their products to pass or fail.

What cannabis operators need to understand about cannabis testing results

Historically, there was an education gap on the side of the operators when it came to interpreting results. The regulated cannabis industry is still quite new and cannabis operators were initially focused on getting products to market. While there was always a focus on regulatory compliance and safety, the same level of quality control that existed in other regulated industries like food production seemed to lag. That has changed as operators have become more sophisticated and are hiring experts skilled in interpreting results and quality control. For a laboratory, hiring scientists with a regulatory background offers the operators the experience needed to ensure they’re getting accurate results that are easy to understand. This has led to more meaningful collaboration between labs and operators who work together to understand what test results mean to their processes and business operations.

A common problem is that some operators see testing as just a speed bump. This doesn’t have to be the case. Third-party testing is an integral part of getting safe products to consumers. Businesses need to find a lab that understands their objectives and knows how to support the manufacturing and production cycles. Establishing a testing protocol with a lab will help ensure that there are no surprises and that products can be tested and sold as quickly as possible.

Now that operators and labs are speaking the same language, the challenge becomes translating that information into a consumer-friendly format. Consumers don’t necessarily need (or want) to explore the minutiae of every tested analyte, but they can easily grasp high level results in the form of charts and graphs. Translating the testing results into an easy-to-digest format allows consumers to better understand the products they are buying.

What are the main components of test results cannabis businesses should look for?

The first and most obvious results to look for is what was tested and if any tests delivered a failing result. A failing result is determined by comparing the tested values against the state requirements. If a product has failed testing in any area, operators will need to work with the lab and their internal teams to determine exactly what the issue is and if it can be rectified. Failing of any state required test (pesticide, microbial, metals, ….) means the product cannot be sold in its current form. Depending on the state, failing results may be required to be confirmed by another lab, processed further to remove the failing contaminants or destroyed. The production cycle to grow, process and manufacture cannabis products can take anywhere from 120 to 160 days with many different processes and handlers. Despite attempts to control all the variables that impact final product quality, failing tests do occur.

Once businesses have passed the state-required testing, the remaining tests are focused on product characteristics including potency and terpene profile. The potency of a product measures the levels of cannabinoids and influences both production and marketing decisions. Lower potency flower may be extracted for distillate products while higher potency flower will demand a higher price and will most likely be sold as flower or processed into concentrate products. Cannabinoid profiles go well beyond just CBD and THC. Understanding the full cannabinoid profile of a product is an important factor in how it can be marketed, and how it will be used.

The terpene profile of a product is also quickly becoming just as important to medical and adult use consumers. Terpenes play a major role in the effects that consumers experience with cannabis products. In the past, consumers relied heavily on strain names to purchase products that they believed would give them the effects that they were looking to achieve. Moving forward, we believe that consumers will be more interested in a product’s terpene profile given the strong influence that terpenes have on effects. In states like Nevada, cannabis businesses put terpene profiles on their product labels and cannabis consumers are starting to select products based on terpenes rather than raw potency numbers.

What is the most important factor in cannabis testing results?

Trust is the most important factor when testing cannabis. Operators need to trust that their lab is providing consistent, accurate and timely results. Consumers need to be able to trust what they read on the certificate of analysis, and they ultimately need to trust that the products they buy will deliver the effects that they expect.

The easiest way for businesses to increase trust in their products and testing results is transparency. When there is transparency from the testing lab to the business and customers, it will help build trust and establish a brand for the long term.

Another important aspect of this process is ensuring businesses share the right information with consumers and educate them as to what it means to them. Information overload, without explanation, will only lead to confusion. It’s important to educate employees, especially those interfacing with customers, on how to interpret and explain test results in a way that consumers can understand.

It can be challenging to translate highly technical test results into consumer-friendly language but being able to do so will enable businesses to build a stronger relationship with customers. This isn’t something that businesses need to figure out by themselves. Rely on your trusted lab partners to help design and deliver easy to understand, consumer friendly certificates of analysis. Consumers want to be educated and understand what is in their products, and how the products will work for them. Trust, transparency and education will help cannabis operators strengthen relationships and continue to grow their business.

The explosive, unregulated growth of delta-8 tetrahydrocannabinol (THC) is coming with a dangerous consequence: Poison control centers across the country are reporting a rise in calls from those who have ingested the cannabinoid. 

At least four states have issued public warnings regarding the cannabinoid, according to local news reports: Michigan, West Virginia, Virginia and North Carolina.

So far this year, as of July, the North Carolina Poison Control Center reported 157 cases related to delta-8, according to the Winston-Salem Journal. Virginia is reporting “dozens” of calls this year.

The rise in calls can be attributed to a number of factors, from the market’s lack of standards to delta-8’s accessibility to minors.

But perhaps the most concerning cause for an increase in delta-8 poison center calls is due to mislabeling–in some cases, consumers hoping to buy these products may be purchasing unregulated, illegal cannabis without knowing.

“This is part and parcel for what happens when you have an unregulated market,” says Jonathan Miller, general counsel for U.S. Hemp Roundtable. 

Mislabeling Plays a Role

A recently published report shines a light on just how prominent mislabeling is in the industry.  Leafreport.com, a peer-reviewed watchdog website for the cannabidiol (CBD) industry, found that more than half of the 38 products it tested had illegal levels of delta-9 THC. In addition, only 32% had the advertised amount of delta-8. The rest were off by 10.7% to 102.7% from the label.

And Wayne State University, based in Michigan, reports that law enforcement agencies in Michigan have seized delta-8 products that were falsely labeled as CBD products.

Lev Spivak-Birndorf, Ph.D., chief science officer at PSI Labs, a Michigan-based cannabis testing lab, says the mislabeling of these products could be linked to the risks associated with producing delta-8, as byproducts can be left during the process of converting it from CBD or delta-9 THC.

For example, when labs extract cannabis to make other oils, it’s a more straightforward process, as there are already established and known solvents and methods, like butane or ethanol extraction, that labs can use to remove byproducts, Spivak-Birndorf says.

“But once you get into the process of converting CBD into delta-8, it’s called chemical synthesis,” he says. “You’re essentially taking one molecule and performing a chemical reaction that’s causing it to change into another molecule via that reaction.”

There are several standard operating procedures (SOPs) that can be used to extract delta-8; however, there are many “variables in terms of what can be left over in the product and how dangerous the substance is that labs use to catalyze that reaction and make it occur at a speed that’s acceptable for production,” he says.

PSI Labs has not yet conducted extensive research into what type of contaminants can be found in delta-8 products due to costs; however, the laboratory has brought in off-the-shelf delta-8 products from places like vape shops and gas stations for testing, and they’ve discovered discrepancies in the products.

“We often find that some of [the products] are very pure delta-8, but still contain traces of delta-9 that are technically above the legal 0.3% THC limit,” he says. “It’s just a mixed bag, and that’s what I think is so risky about it, is that it’s very uncontrolled in terms of these processes, where one product could be pretty genuine to its label, but another one might be very different.”

RELATED: Understanding Delta-8-THC: Where Does It Come From?

Allison Justice, Ph.D., CEO of The Hemp Mine, previously told Hemp Grower that in the delta-8 extraction process, the final distillate ends up being 60% to 70% delta-8 and roughly 2% to 6% delta-9. Suppose a company wants to make a compliant product with the U.S. Department of Agriculture’s (USDA’s) final rule on hemp. In that case, they will then run the distillate through extensive chromatography to remove the delta-9 or dilute it down to ensure it’s under the 0.3% THC limit, she said.

But Spivak-Birndorf says PSI Labs has found off-the-shelf delta-8 products that contain 20% delta-9, as well as a significant amount of CBD, meaning that whatever reaction pathway they chose, they didn’t finish it and left it “half-cooked,” he says.

“This raises lots of questions about what residual other byproducts might be in [the delta-8 products] that are sort of not familiar cannabinoids, but maybe harmful substances, like heavy metals, which can often be used in these processes,” he says.

Spivak-Birndorf says PSI Labs has come across many delta-8 vapes over the 0.3% THC limit; however, he thinks the real risk with mislabeling is with edibles. 

“Once you eat [the edible], that’s how much you eat, and you really can’t go back from there. So, that’s where testing is absolutely critical,” he says. “You really need to test things in a fashionable manner to make sure that there’s nothing wrong with your process. Other packaged and ready-made goods go through many good manufacturing practices (GMPs) and Food and Drug Administration (FDA) guidelines before they get to the shelf. In the cannabis industry, a lot of that stuff is non-existent or just catching up.”

Spivak-Birndorf says there is a need for third-party, end-product testing on a batch basis to ensure the products are correctly dosed before hitting shelves because there are not many regulated delta-8 testing and measurement practices in place.

“All of this is an important part of a good manufacturing practice of what goes into all the packaged goods we consume,” he says. “And so really, it should be implemented for delta-8 or delta-9, just like anything else.”

“There’s no reason to limit ourselves in terms of the cannabinoid toolbox,” he adds. “Whether it’s naturally occurring, semi-synthetic or even synthetic, it’s very important to know exactly what we’re dealing with and what quantities we’re dealing with if we want to avoid unknown adverse reactions and keep people as safe and healthy as possible.”

Minors the Main Victims

According to the Wayne State University report, in a nearby state, there were two reported cases of severe adverse reactions to delta-8 in children who ingested their father’s edibles purchased at a vape shop.

The report says that because delta-8 products are packaged in similar forms of CBD, teens and young children have a higher risk of using the compound accidentally. “THC use in children can cause low blood pressure, difficulty breathing, severe sedation, coma, and psychological effects. Long-term effects in children are not known,” the report says.

According to the National Capital Poison Center, because delta-8 products are largely unregulated, “the packaging may not be child-resistant and may contain cartoon-like images or other features that may be appealing to children.”

On its website, the National Capital Poison Center offers this anecdote: “A 3-year-old boy was brought to an Emergency Department after eating an unknown amount of delta-8 THC gummies belonging to his mother. The gummies were packaged in a container with a twist-off top, and the boy was able to open the container by himself. The child experienced vomiting but was eventually released from the hospital. His mother was cited for child abuse and neglect.”

Market Regulation Needed

Spivak-Birndorf says there is an increased need for regulation, as it is difficult to trace where these unsafe delta-8 products are coming from.

“While some of these companies have an online presence and show current testing and are actually responsible, for every one of those, there’s probably, and I would guess, numerous [companies] that are flying by night and just not checking their work,” he says. “Or they’re not concerned about quality control checks for their product, which they should have. So, definitely without that regulatory push to do all that stuff, it’s unrealistic to think that [everyone] is just going to take that upon themselves.”

As previously reported by Hemp Grower, Michigan has recently joined numerous other states in regulating delta-8, as Gov. Gretchen Whitmer signed legislation into law July 13, prohibiting businesses from selling delta-8 products without proper licensing from the Michigan Marijuana Regulatory Agency, and the products must be tracked and tested like any other cannabis product. 

Additionally, “the new law also bars businesses without state cannabis licenses from producing and selling any other potentially intoxicating cannabis compounds,” Hemp Grower previously reported.

And in late April, Hemp Grower reported that Washington’s Liquor and Cannabis Board (LCB) issued a policy statement, stating that “Delta-8 THC, as well as derivatives, extracts, cannabinoids, isomers, and CBD isolate from hemp or other sources that are genetically or chemically altered into compounds may not be produced or processed in LCB licensed facilities, and may not be sold in licensed marijuana retail stores.”

However, this does not necessarily mean delta-8 is outright banned in the state, as the LCB’s notice “was only an interpretation of the law as it relates to the legal cannabis market,” Hemp Grower reported.

Washington and Michigan are just two of nearly 20 states that have already regulated the cannabinoid. According to Hemp Grower, 15 states have issued bans on delta-8, while six additional states have pending legislation to regulate the cannabinoid and related THC isomers. 

Miller says the U.S. Hemp Roundtable has been working with states on developing laws that regulate delta-8 under the cannabis market because of its psychoactive properties. So far, Michigan, Oregon and New York have passed similar laws.

“I would very much hesitate buying a delta-8 product” in the current market, Miller says. “I would only buy things available in a dispensary that have been proven to undergo the same type of testing [as regulated cannabis].”

Not Just Delta-8

Delta-8 isn’t the only cannabinoid responsible for an uptick in poison center calls this year.

As of June 30, the American Association of Poison Control Centers (AAPCC) reported that poison control centers across the country had managed 2,158 cases in 2021 related to CBD. This is nearly on par with the 2,226 calls placed the entire year in 2020.

For perspective, in June 2020, poison control centers handled 181 cases related to CBD; in June 2021, that number jumped to 423.

The AAPCC offers this explanation on its website for the increase in calls: “…[S]ome products contain more CBD than what is on the label, more THC than labeled, or other chemical compounds/drug ingredients that are not listed at all. Consumers have no way of knowing whether the product is contaminated with other chemicals and drugs or labeled correctly.”

© Chart Courtesy of The American Association of Poison Control Centers

Miller points out that CBD is “a safe compound, and study after study have demonstrated its safety.” But without clear regulations or even guidance on how to produce CBD products, it’s possible the products contributing to poison control center cases don’t comply with GMP safety standards, Miller says.

“The challenge is that we’re in an unregulated marketplace,” he says. “These kinds of problems are hopefully going to spur Congressional action that will pass bills to develop a regulatory structure.”

Miller adds that the Hemp Access and Consumer Safety Act moving through the U.S. Senate would require the U.S. Food and Drug Administration to develop a regulatory pathway for CBD to be used in food, beverages and dietary supplements.

You can reach your local poison control center by calling the Poison Help hotline: 1-800-222-1222. To save the number in your mobile phone, text POISON to 797979.

 

The explosive, unregulated growth of delta-8 tetrahydrocannabinol (THC) is coming with a dangerous consequence: Poison control centers across the country are reporting a rise in calls from those who have ingested the cannabinoid. 

At least four states have issued public warnings regarding the cannabinoid, according to local news reports: Michigan, West Virginia, Virginia and North Carolina.

So far this year, as of July, the North Carolina Poison Control Center reported 157 cases related to delta-8, according to the Winston-Salem Journal. Virginia is reporting “dozens” of calls this year.

The rise in calls can be attributed to a number of factors, from the market’s lack of standards to delta-8’s accessibility to minors.

But perhaps the most concerning cause for an increase in delta-8 poison center calls is due to mislabeling–in some cases, consumers hoping to buy these products may be purchasing unregulated, illegal cannabis without knowing.

“This is part and parcel for what happens when you have an unregulated market,” says Jonathan Miller, general counsel for U.S. Hemp Roundtable. 

Mislabeling Plays a Role

A recently published report shines a light on just how prominent mislabeling is in the industry.  Leafreport.com, a peer-reviewed watchdog website for the cannabidiol (CBD) industry, found that more than half of the 38 products it tested had illegal levels of delta-9 THC. In addition, only 32% had the advertised amount of delta-8. The rest were off by 10.7% to 102.7% from the label.

And Wayne State University, based in Michigan, reports that law enforcement agencies in Michigan have seized delta-8 products that were falsely labeled as CBD products.

Lev Spivak-Birndorf, Ph.D., chief science officer at PSI Labs, a Michigan-based cannabis testing lab, says the mislabeling of these products could be linked to the risks associated with producing delta-8, as byproducts can be left during the process of converting it from CBD or delta-9 THC.

For example, when labs extract cannabis to make other oils, it’s a more straightforward process, as there are already established and known solvents and methods, like butane or ethanol extraction, that labs can use to remove byproducts, Spivak-Birndorf says.

“But once you get into the process of converting CBD into delta-8, it’s called chemical synthesis,” he says. “You’re essentially taking one molecule and performing a chemical reaction that’s causing it to change into another molecule via that reaction.”

There are several standard operating procedures (SOPs) that can be used to extract delta-8; however, there are many “variables in terms of what can be left over in the product and how dangerous the substance is that labs use to catalyze that reaction and make it occur at a speed that’s acceptable for production,” he says.

PSI Labs has not yet conducted extensive research into what type of contaminants can be found in delta-8 products due to costs; however, the laboratory has brought in off-the-shelf delta-8 products from places like vape shops and gas stations for testing, and they’ve discovered discrepancies in the products.

“We often find that some of [the products] are very pure delta-8, but still contain traces of delta-9 that are technically above the legal 0.3% THC limit,” he says. “It’s just a mixed bag, and that’s what I think is so risky about it, is that it’s very uncontrolled in terms of these processes, where one product could be pretty genuine to its label, but another one might be very different.”

RELATED: Understanding Delta-8-THC: Where Does It Come From?

Allison Justice, Ph.D., CEO of The Hemp Mine, previously told Hemp Grower that in the delta-8 extraction process, the final distillate ends up being 60% to 70% delta-8 and roughly 2% to 6% delta-9. Suppose a company wants to make a compliant product with the U.S. Department of Agriculture’s (USDA’s) final rule on hemp. In that case, they will then run the distillate through extensive chromatography to remove the delta-9 or dilute it down to ensure it’s under the 0.3% THC limit, she said.

But Spivak-Birndorf says PSI Labs has found off-the-shelf delta-8 products that contain 20% delta-9, as well as a significant amount of CBD, meaning that whatever reaction pathway they chose, they didn’t finish it and left it “half-cooked,” he says.

“This raises lots of questions about what residual other byproducts might be in [the delta-8 products] that are sort of not familiar cannabinoids, but maybe harmful substances, like heavy metals, which can often be used in these processes,” he says.

Spivak-Birndorf says PSI Labs has come across many delta-8 vapes over the 0.3% THC limit; however, he thinks the real risk with mislabeling is with edibles. 

“Once you eat [the edible], that’s how much you eat, and you really can’t go back from there. So, that’s where testing is absolutely critical,” he says. “You really need to test things in a fashionable manner to make sure that there’s nothing wrong with your process. Other packaged and ready-made goods go through many good manufacturing practices (GMPs) and Food and Drug Administration (FDA) guidelines before they get to the shelf. In the cannabis industry, a lot of that stuff is non-existent or just catching up.”

Spivak-Birndorf says there is a need for third-party, end-product testing on a batch basis to ensure the products are correctly dosed before hitting shelves because there are not many regulated delta-8 testing and measurement practices in place.

“All of this is an important part of a good manufacturing practice of what goes into all the packaged goods we consume,” he says. “And so really, it should be implemented for delta-8 or delta-9, just like anything else.”

“There’s no reason to limit ourselves in terms of the cannabinoid toolbox,” he adds. “Whether it’s naturally occurring, semi-synthetic or even synthetic, it’s very important to know exactly what we’re dealing with and what quantities we’re dealing with if we want to avoid unknown adverse reactions and keep people as safe and healthy as possible.”

Minors the Main Victims

According to the Wayne State University report, in a nearby state, there were two reported cases of severe adverse reactions to delta-8 in children who ingested their father’s edibles purchased at a vape shop.

The report says that because delta-8 products are packaged in similar forms of CBD, teens and young children have a higher risk of using the compound accidentally. “THC use in children can cause low blood pressure, difficulty breathing, severe sedation, coma, and psychological effects. Long-term effects in children are not known,” the report says.

According to the National Capital Poison Center, because delta-8 products are largely unregulated, “the packaging may not be child-resistant and may contain cartoon-like images or other features that may be appealing to children.”

On its website, the National Capital Poison Center offers this anecdote: “A 3-year-old boy was brought to an Emergency Department after eating an unknown amount of delta-8 THC gummies belonging to his mother. The gummies were packaged in a container with a twist-off top, and the boy was able to open the container by himself. The child experienced vomiting but was eventually released from the hospital. His mother was cited for child abuse and neglect.”

Market Regulation Needed

Spivak-Birndorf says there is an increased need for regulation, as it is difficult to trace where these unsafe delta-8 products are coming from.

“While some of these companies have an online presence and show current testing and are actually responsible, for every one of those, there’s probably, and I would guess, numerous [companies] that are flying by night and just not checking their work,” he says. “Or they’re not concerned about quality control checks for their product, which they should have. So, definitely without that regulatory push to do all that stuff, it’s unrealistic to think that [everyone] is just going to take that upon themselves.”

As previously reported by Hemp Grower, Michigan has recently joined numerous other states in regulating delta-8, as Gov. Gretchen Whitmer signed legislation into law July 13, prohibiting businesses from selling delta-8 products without proper licensing from the Michigan Marijuana Regulatory Agency, and the products must be tracked and tested like any other cannabis product. 

Additionally, “the new law also bars businesses without state cannabis licenses from producing and selling any other potentially intoxicating cannabis compounds,” Hemp Grower previously reported.

And in late April, Hemp Grower reported that Washington’s Liquor and Cannabis Board (LCB) issued a policy statement, stating that “Delta-8 THC, as well as derivatives, extracts, cannabinoids, isomers, and CBD isolate from hemp or other sources that are genetically or chemically altered into compounds may not be produced or processed in LCB licensed facilities, and may not be sold in licensed marijuana retail stores.”

However, this does not necessarily mean delta-8 is outright banned in the state, as the LCB’s notice “was only an interpretation of the law as it relates to the legal cannabis market,” Hemp Grower reported.

Washington and Michigan are just two of nearly 20 states that have already regulated the cannabinoid. According to Hemp Grower, 15 states have issued bans on delta-8, while six additional states have pending legislation to regulate the cannabinoid and related THC isomers. 

Miller says the U.S. Hemp Roundtable has been working with states on developing laws that regulate delta-8 under the cannabis market because of its psychoactive properties. So far, Michigan, Oregon and New York have passed similar laws.

“I would very much hesitate buying a delta-8 product” in the current market, Miller says. “I would only buy things available in a dispensary that have been proven to undergo the same type of testing [as regulated cannabis].”

Not Just Delta-8

Delta-8 isn’t the only cannabinoid responsible for an uptick in poison center calls this year.

As of June 30, the American Association of Poison Control Centers (AAPCC) reported that poison control centers across the country had managed 2,158 cases in 2021 related to CBD. This is nearly on par with the 2,226 calls placed the entire year in 2020.

For perspective, in June 2020, poison control centers handled 181 cases related to CBD; in June 2021, that number jumped to 423.

The AAPCC offers this explanation on its website for the increase in calls: “…[S]ome products contain more CBD than what is on the label, more THC than labeled, or other chemical compounds/drug ingredients that are not listed at all. Consumers have no way of knowing whether the product is contaminated with other chemicals and drugs or labeled correctly.”

© Chart Courtesy of The American Association of Poison Control Centers

Miller points out that CBD is “a safe compound, and study after study have demonstrated its safety.” But without clear regulations or even guidance on how to produce CBD products, it’s possible the products contributing to poison control center cases don’t comply with GMP safety standards, Miller says.

“The challenge is that we’re in an unregulated marketplace,” he says. “These kinds of problems are hopefully going to spur Congressional action that will pass bills to develop a regulatory structure.”

Miller adds that the Hemp Access and Consumer Safety Act moving through the U.S. Senate would require the U.S. Food and Drug Administration to develop a regulatory pathway for CBD to be used in food, beverages and dietary supplements.

You can reach your local poison control center by calling the Poison Help hotline: 1-800-222-1222. To save the number in your mobile phone, text POISON to 797979.

 

The explosive, unregulated growth of delta-8 tetrahydrocannabinol (THC) is coming with a dangerous consequence: Poison control centers across the country are reporting a rise in calls from those who have ingested the cannabinoid. 

At least four states have issued public warnings regarding the cannabinoid, according to local news reports: Michigan, West Virginia, Virginia and North Carolina.

So far this year, as of July, the North Carolina Poison Control Center reported 157 cases related to delta-8, according to the Winston-Salem Journal. Virginia is reporting “dozens” of calls this year.

The rise in calls can be attributed to a number of factors, from the market’s lack of standards to delta-8’s accessibility to minors.

But perhaps the most concerning cause for an increase in delta-8 poison center calls is due to mislabeling–in some cases, consumers hoping to buy these products may be purchasing unregulated, illegal cannabis without knowing.

“This is part and parcel for what happens when you have an unregulated market,” says Jonathan Miller, general counsel for U.S. Hemp Roundtable. 

Mislabeling Plays a Role

A recently published report shines a light on just how prominent mislabeling is in the industry.  Leafreport.com, a peer-reviewed watchdog website for the cannabidiol (CBD) industry, found that more than half of the 38 products it tested had illegal levels of delta-9 THC. In addition, only 32% had the advertised amount of delta-8. The rest were off by 10.7% to 102.7% from the label.

And Wayne State University, based in Michigan, reports that law enforcement agencies in Michigan have seized delta-8 products that were falsely labeled as CBD products.

Lev Spivak-Birndorf, Ph.D., chief science officer at PSI Labs, a Michigan-based cannabis testing lab, says the mislabeling of these products could be linked to the risks associated with producing delta-8, as byproducts can be left during the process of converting it from CBD or delta-9 THC.

For example, when labs extract cannabis to make other oils, it’s a more straightforward process, as there are already established and known solvents and methods, like butane or ethanol extraction, that labs can use to remove byproducts, Spivak-Birndorf says.

“But once you get into the process of converting CBD into delta-8, it’s called chemical synthesis,” he says. “You’re essentially taking one molecule and performing a chemical reaction that’s causing it to change into another molecule via that reaction.”

There are several standard operating procedures (SOPs) that can be used to extract delta-8; however, there are many “variables in terms of what can be left over in the product and how dangerous the substance is that labs use to catalyze that reaction and make it occur at a speed that’s acceptable for production,” he says.

PSI Labs has not yet conducted extensive research into what type of contaminants can be found in delta-8 products due to costs; however, the laboratory has brought in off-the-shelf delta-8 products from places like vape shops and gas stations for testing, and they’ve discovered discrepancies in the products.

“We often find that some of [the products] are very pure delta-8, but still contain traces of delta-9 that are technically above the legal 0.3% THC limit,” he says. “It’s just a mixed bag, and that’s what I think is so risky about it, is that it’s very uncontrolled in terms of these processes, where one product could be pretty genuine to its label, but another one might be very different.”

RELATED: Understanding Delta-8-THC: Where Does It Come From?

Allison Justice, Ph.D., CEO of The Hemp Mine, previously told Hemp Grower that in the delta-8 extraction process, the final distillate ends up being 60% to 70% delta-8 and roughly 2% to 6% delta-9. Suppose a company wants to make a compliant product with the U.S. Department of Agriculture’s (USDA’s) final rule on hemp. In that case, they will then run the distillate through extensive chromatography to remove the delta-9 or dilute it down to ensure it’s under the 0.3% THC limit, she said.

But Spivak-Birndorf says PSI Labs has found off-the-shelf delta-8 products that contain 20% delta-9, as well as a significant amount of CBD, meaning that whatever reaction pathway they chose, they didn’t finish it and left it “half-cooked,” he says.

“This raises lots of questions about what residual other byproducts might be in [the delta-8 products] that are sort of not familiar cannabinoids, but maybe harmful substances, like heavy metals, which can often be used in these processes,” he says.

Spivak-Birndorf says PSI Labs has come across many delta-8 vapes over the 0.3% THC limit; however, he thinks the real risk with mislabeling is with edibles. 

“Once you eat [the edible], that’s how much you eat, and you really can’t go back from there. So, that’s where testing is absolutely critical,” he says. “You really need to test things in a fashionable manner to make sure that there’s nothing wrong with your process. Other packaged and ready-made goods go through many good manufacturing practices (GMPs) and Food and Drug Administration (FDA) guidelines before they get to the shelf. In the cannabis industry, a lot of that stuff is non-existent or just catching up.”

Spivak-Birndorf says there is a need for third-party, end-product testing on a batch basis to ensure the products are correctly dosed before hitting shelves because there are not many regulated delta-8 testing and measurement practices in place.

“All of this is an important part of a good manufacturing practice of what goes into all the packaged goods we consume,” he says. “And so really, it should be implemented for delta-8 or delta-9, just like anything else.”

“There’s no reason to limit ourselves in terms of the cannabinoid toolbox,” he adds. “Whether it’s naturally occurring, semi-synthetic or even synthetic, it’s very important to know exactly what we’re dealing with and what quantities we’re dealing with if we want to avoid unknown adverse reactions and keep people as safe and healthy as possible.”

Minors the Main Victims

According to the Wayne State University report, in a nearby state, there were two reported cases of severe adverse reactions to delta-8 in children who ingested their father’s edibles purchased at a vape shop.

The report says that because delta-8 products are packaged in similar forms of CBD, teens and young children have a higher risk of using the compound accidentally. “THC use in children can cause low blood pressure, difficulty breathing, severe sedation, coma, and psychological effects. Long-term effects in children are not known,” the report says.

According to the National Capital Poison Center, because delta-8 products are largely unregulated, “the packaging may not be child-resistant and may contain cartoon-like images or other features that may be appealing to children.”

On its website, the National Capital Poison Center offers this anecdote: “A 3-year-old boy was brought to an Emergency Department after eating an unknown amount of delta-8 THC gummies belonging to his mother. The gummies were packaged in a container with a twist-off top, and the boy was able to open the container by himself. The child experienced vomiting but was eventually released from the hospital. His mother was cited for child abuse and neglect.”

Market Regulation Needed

Spivak-Birndorf says there is an increased need for regulation, as it is difficult to trace where these unsafe delta-8 products are coming from.

“While some of these companies have an online presence and show current testing and are actually responsible, for every one of those, there’s probably, and I would guess, numerous [companies] that are flying by night and just not checking their work,” he says. “Or they’re not concerned about quality control checks for their product, which they should have. So, definitely without that regulatory push to do all that stuff, it’s unrealistic to think that [everyone] is just going to take that upon themselves.”

As previously reported by Hemp Grower, Michigan has recently joined numerous other states in regulating delta-8, as Gov. Gretchen Whitmer signed legislation into law July 13, prohibiting businesses from selling delta-8 products without proper licensing from the Michigan Marijuana Regulatory Agency, and the products must be tracked and tested like any other cannabis product. 

Additionally, “the new law also bars businesses without state cannabis licenses from producing and selling any other potentially intoxicating cannabis compounds,” Hemp Grower previously reported.

And in late April, Hemp Grower reported that Washington’s Liquor and Cannabis Board (LCB) issued a policy statement, stating that “Delta-8 THC, as well as derivatives, extracts, cannabinoids, isomers, and CBD isolate from hemp or other sources that are genetically or chemically altered into compounds may not be produced or processed in LCB licensed facilities, and may not be sold in licensed marijuana retail stores.”

However, this does not necessarily mean delta-8 is outright banned in the state, as the LCB’s notice “was only an interpretation of the law as it relates to the legal cannabis market,” Hemp Grower reported.

Washington and Michigan are just two of nearly 20 states that have already regulated the cannabinoid. According to Hemp Grower, 15 states have issued bans on delta-8, while six additional states have pending legislation to regulate the cannabinoid and related THC isomers. 

Miller says the U.S. Hemp Roundtable has been working with states on developing laws that regulate delta-8 under the cannabis market because of its psychoactive properties. So far, Michigan, Oregon and New York have passed similar laws.

“I would very much hesitate buying a delta-8 product” in the current market, Miller says. “I would only buy things available in a dispensary that have been proven to undergo the same type of testing [as regulated cannabis].”

Not Just Delta-8

Delta-8 isn’t the only cannabinoid responsible for an uptick in poison center calls this year.

As of June 30, the American Association of Poison Control Centers (AAPCC) reported that poison control centers across the country had managed 2,158 cases in 2021 related to CBD. This is nearly on par with the 2,226 calls placed the entire year in 2020.

For perspective, in June 2020, poison control centers handled 181 cases related to CBD; in June 2021, that number jumped to 423.

The AAPCC offers this explanation on its website for the increase in calls: “…[S]ome products contain more CBD than what is on the label, more THC than labeled, or other chemical compounds/drug ingredients that are not listed at all. Consumers have no way of knowing whether the product is contaminated with other chemicals and drugs or labeled correctly.”

© Chart Courtesy of The American Association of Poison Control Centers

Miller points out that CBD is “a safe compound, and study after study have demonstrated its safety.” But without clear regulations or even guidance on how to produce CBD products, it’s possible the products contributing to poison control center cases don’t comply with GMP safety standards, Miller says.

“The challenge is that we’re in an unregulated marketplace,” he says. “These kinds of problems are hopefully going to spur Congressional action that will pass bills to develop a regulatory structure.”

Miller adds that the Hemp Access and Consumer Safety Act moving through the U.S. Senate would require the U.S. Food and Drug Administration to develop a regulatory pathway for CBD to be used in food, beverages and dietary supplements.

You can reach your local poison control center by calling the Poison Help hotline: 1-800-222-1222. To save the number in your mobile phone, text POISON to 797979.

 

LAS VEGAS, NV JULY 22, 2021 – Cannabis Conference, produced by parent company GIE Media Inc. and industry-leading Cannabis Business Times, Cannabis Dispensary, and Hemp Grower magazines, announces today Sherbinskis’ Founder and Chief Creative Officer Mario Guzman as the keynote speaker on Day 1 of its annual event, to take place Aug. 24-26, 2021, at Paris Las Vegas Hotel & Casino.

In a Fireside Chat led by Cannabis Conference Digital Editor Eric Sandy, Guzman will share his dynamic cannabis story—from his humble beginnings as an entrepreneur working from his garage to becoming a world-famous tastemaker and curator of high-quality genetics. He will discuss lessons learned along the way, from scaling his business in California to finding multi-state and retail partners, as well as recognizing the importance of diversity and inclusion in his business model. Guzman will also share emerging trends in cannabis genetics, medical research, ‘seed-to-scale’ cultivation and much more.   

The keynote will take place on Tuesday, Aug. 24 from 2:10 p.m. – 3:10 p.m. PT.

Guzman has been a key player in the medical cannabis movement for more than 20 years, breeding and cultivating internationally renowned genetics like Pink Panties, Sunset Sherbert and the Gelato line. Guzman, who recently joined the Board of Directors for the Minority Cannabis Business Association, says his desire to serve stems from his motivation to ensure that the next generation of minority cannabis business professionals have the assistance and guidance from other minorities that he wasn’t fortunate enough to have.

“It’s exciting to participate in an event that’s curated for us—people in plant-touching operations. As cultivators and retailers of cannabis, we uniquely understand the labor of love it is to grow this plant, and how important it is to work through industry challenges with the utmost integrity and the consumer top of mind,” Guzman said. “I’m looking forward to sharing stories from my own journey these past two decades, as well as connecting with others pushing the industry forward and becoming vehicles for change for communities of color.” 

“Mario has the respect of his peers in the industry and has achieved such strong brand recognition—something every plant-touching cannabis business strives for. We are thrilled to have him as such a big part of the Cannabis Conference,” said Cannabis Conference Editorial Director Noelle Skodzinski. “He is a trailblazer who has not only persisted but thrived over two turbulent decades in the cannabis industry, and long-time cannabis businesses as well as newcomers to the industry have much to learn from his experiences and successes.”

More information about Cannabis Conference, including sessions, speakers, exhibitors and FAQs, can be found at www.CannabisConference.com. Rates will increase July 31, 2021. Click hereto review pricing and to register.

 

About Cannabis Conference

Cannabis Conference 2021, presented by the award-winning Cannabis Business Times, Cannabis Dispensary, and Hemp Grower media brands, is the leading educational provider for plant-touching businesses in the legal cannabis and hemp markets. The three-day event will take place at Paris Las Vegas Hotel & Casino in Las Vegas, Nev., on Aug. 24-26, 2021. The Cannabis Conference exhibition hall will feature 170+ industry-leading technologies, solutions and services for the professional cannabis cultivator and retail businesses. For more information, visit www.CannabisConference.com.

About GIE Media

GIE Media was founded in 1980 and has grown over 41 years into a leading marketing and communications business-to-business media company serving 17 industries—including the horticulture industry through its Horticulture Group (Greenhouse Management, Produce Grower, Nursery Management, Garden Center, Cannabis Business Times, Cannabis Dispensary and Hemp Grower). The company employs nearly 100 editors, publishers, sales representatives, marketers and other professionals. For more information, visit www.GIEMedia.com.